Alcohol in moderation does no harm. There are studies to indicate that an occasional glass of wine may have some therapeutic effect. Alcohol is an important medium of administration of homeopathic medicine to people with glucose intolerance. Wine is integral to some Western cultures. Prohibition in the 1930s did not work because it went against the basic grain of communities that had immigrated from lands where alcohol was weaved in to lifestyles. The Mafia flourished because of corruption in the Police force.
Now we are on another plane. Drugs have benefit only for those who are terminally ill and is available for them in the form of prescribed medicine. Its addictive power is deadly. Modern society does not endorse its use. It can make you haluucinate and lose control of your faculties in a flash. I do not know of a single case of a person who takes drugs and is able to live a normal life.
Afghans who lead the world in drug cultivation don't touch the stuff themselves!